VLDL Receptor
Gene Ontology | |
---|---|
Molecular function | • glycoprotein binding • low-density lipoprotein receptor activity • calcium ion binding • protein binding • very-low-density lipoprotein particle receptor activity • apolipoprotein binding • very-low-density lipoprotein particle binding • glycoprotein transporter activity • reelin receptor activity • calcium-dependent protein binding |
Cellular component | • nucleus • plasma membrane • coated pit • cell surface • membrane • integral to membrane • very-low-density lipoprotein particle • apical part of cell • perinuclear region of cytoplasm |
Biological process | • negative regulation of transcription from RNA polymerase II promoter • lipid transport • receptor-mediated endocytosis • signal transduction • nervous system development • heart development • response to nutrient • memory • cholesterol metabolic process • ventral spinal cord development • cerebral cortex development • cellular response to insulin stimulus • glycoprotein transport • very-low-density lipoprotein particle clearance • reelin-mediated signaling pathway • cellular response to glucose starvation • response to drug • positive regulation of protein kinase activity • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to hypoxia • positive regulation of dendrite development |
Sources: Amigo / QuickGO |
2.62 – 2.65 Mb
27.22 – 27.25 Mb
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.
Read more about VLDL Receptor: Protein Structure, Ligand Binding, Tissue Distribution and Expression, Associated Disorders
Famous quotes containing the word receptor:
“The disinterest [of my two great-aunts] in anything that had to do with high society was such that their sense of hearing ... put to rest its receptor organs and allowed them to suffer the true beginnings of atrophy.”
—Marcel Proust (18711922)