Vinculin Binding Site
| VBS | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969) | |||||||||
| Identifiers | |||||||||
| Symbol | VBS | ||||||||
| Pfam | PF08913 | ||||||||
| InterPro | IPR015009 | ||||||||
Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod. Read more about this topic: Vinculin Famous quotes containing the words binding and/or site:“Hate traps us by binding us too tightly to our adversary.” “That is a pathetic inquiry among travelers and geographers after the site of ancient Troy. It is not near where they think it is. When a thing is decayed and gone, how indistinct must be the place it occupied!” | |||||||||