Other
- Vile (Mega Man X), a character from the Mega Man X game series
- Doctor Vile, The original Japanese name for Dr. Weil, the main antagonist from the Mega Man Zero game series
- Vile (editor), text editor
- V.I.L.E., the name of a fictional villain group in the Carmen Sandiego series
- Vile Parle, a suburb of Mumbai in India
- Vile, Portugal, a small town in northern Portugal
- Vile, Denmark, a small area on the western coast
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