Vesica (plural vesicae) is Latin for "bladder", and may refer to:
- Anatomy
- Vesica, mainly used for the urinary bladder, also used for the gall bladder and in entomology for a part of the male genitals.
- Trigonum vesicae urinariae, Latin for trigone of urinary bladder
- Shapes
- Vesica piscis, a shape formed by the intersection of two circles of the same radius