Subtypes
There are three subtypes of vasopressin receptor: V1A (V1), V1B (V3) and V2.
| Subtype (symbol) | Signalling pathways | Location | Function | ||
|---|---|---|---|---|---|
| gene | receptor | ||||
| IUPHAR | alternate | ||||
| AVPR1A | V1A | V1 | G protein-coupled, phosphatidylinositol/calcium | vascular smooth muscle, platelet, hepatocytes, myometrium | vasoconstriction, myocardial hypertrophy, platelet aggregation, glycogenolysis, uterine contraction |
| AVPR1B | V1B | V3 | G protein-coupled, phosphatidylinositol/calcium | anterior pituitary gland | releases ACTH, prolactin, endorphins |
| AVPR2 | V2 | V2 | Adenylyl cyclase/cAMP | basolateral membrane of collecting duct, vascular endothelium and vascular smooth muscle cell | insertion of AQP-2 water channels into apical membrane, induction of AQP-2 synthesis, releases von Willebrand factor and factor VIII, vasodilation |
Read more about this topic: Vasopressin Receptor