Major Intersections
| County | Location | Mile | km | Destinations | Notes |
|---|---|---|---|---|---|
| Knox |
Vincennes | 0.00 | 0.00 | US 50 west – Lawrenceville | Illinois state line |
| 1.84 | 2.96 | US 41 north / US 150 west to SR 67 north – Terre Haute | Western end of US 41/US 150 concurrency | ||
| 3.04 | 4.89 | US 41 south – Evansville | Eastern end of US 41 concurrency | ||
| Wheatland | 13.16 | 21.18 | SR 550 west – Emison | Eastern terminus of SR 550 | |
| 13.67 | 22.00 | SR 241 south – Decker | Northern terminus of SR 241 | ||
| Daviess |
Washington | 20.53 | 33.04 | SR 57 – Evansville, Petersburg, Washington, Worthington | |
| 22.72 | 36.56 | SR 257 – Otwell | |||
| I-69 – Evansville | |||||
| Martin |
Loogootee | 36.02 | 57.97 | US 231 south – Jasper | Southern end of US 231 concurrency |
| 36.49 | 58.72 | US 231 north – Bloomfield | Northern end of US 231 concurrency | ||
| 36.78 | 59.19 | SR 550 east | Western terminus of SR 550 | ||
| Center Township | 42.65 | 68.64 | SR 450 east – Bedford | Western terminus of SR 450 | |
| Shoals | 44.18 | 71.10 | US 150 east – Paoli, Louisville | Eastern end of US 150 concurrency | |
| Halbert Township | 48.19 | 77.55 | SR 650 east | Western terminus of SR 650 | |
| Lawrence |
Spice Valley Township | 54.33 | 87.44 | SR 60 east – Mitchell | Western terminus of SR 60 |
| Bedford | 64.09 | 103.14 | SR 37 south – Mitchell | Southern end of SR 37 concurrency | |
| 68.16 | 109.69 | SR 37 north / SR 450 west to SR 158 west – Bloomington | Northern end of SR 37 concurrency; western end of SR 450 concurrency | ||
| 69.88 | 112.46 | SR 450 | Eastern terminus of SR 450 | ||
| Shawswick Township | 78.24 | 125.92 | SR 446 north – Bloomington, Heltonville | Southern terminus of SR 446 | |
| Jackson |
Owen Township | 88.63 | 142.64 | SR 235 south – Medora | Northern terminus of SR 235 |
| 91.27 | 146.88 | SR 135 north – Medora | Western end of SR 135 concurrency | ||
| Brownstown | 94.33 | 151.81 | SR 135 south – Freetown | Eastern end of SR 135 concurrency | |
| 95.12 | 153.08 | SR 250 east | Western terminus of SR 250 | ||
| Seymour | 105.26 | 169.40 | SR 11 south | Western end of SR 11 concurrency | |
| 105.57 | 169.90 | SR 11 north – Columbus | Eastern end of SR 11 concurrency | ||
| 107.83 | 173.54 | I-65 – Indianapolis, Louisville | |||
| 108.30 | 174.29 | US 31 – Scottsburg, Columbus | |||
| Jennings |
North Vernon | 120.54 | 193.99 | SR 3 / SR 7 – Vernon, Columbus, Greensburg | |
| Ripley |
Versailles | 141.07 | 227.03 | US 421 north – Greensburg | Western end of US 421 concurrency |
| 141.99 | 228.51 | US 421 south / SR 129 south – Madison, Vevay | Eastern end of US 421 concurrency; western end of SR 129 concurrency | ||
| Johnson Township — Washington Township |
145.91 | 234.82 | SR 129 north – Batesville | Eastern end of SR 129 concurrency | |
| Washington Township | 149.04 | 239.86 | SR 101 north – Milan | Southern terminus of SR 101 | |
| Dearborn |
Dillsboro | 154.28 | 248.29 | SR 62 west / SR 262 east – Madison, Rising Sun | Eastern terminus of SR 62; eastern terminus of SR 262 |
| Aurora | 163.14 | 262.55 | SR 56 west / SR 350 west – Rising Sun, Osgood | Eastern terminus of SR 56; eastern terminus of SR 350 | |
| 163.63 | 263.34 | SR 148 west | Eastern terminus of SR 148 | ||
| Lawrenceburg Township | 166.59 | 268.10 | SR 48 west – Napoleon | Eastern terminus of SR 48 | |
| Lawrenceburg | 169.07 | 272.09 | I-275 / SR 1 north – Ohio, Kentucky | Southern terminus of SR 1 | |
| Lawrenceburg Township | 171.38 | 275.81 | US 50 east – Cincinnati | Ohio state line | |
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Read more about this topic: U.S. Route 50 In Indiana
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