U.S. Route 421 in North Carolina - Junction List

Junction List

County Location Mile km Exit Destinations Notes
New Hanover
 Fort Fisher 0.2 0.3 Fort Fisher Ferry Terminal US 421 begins .2 miles (0.32 km) south of terminal; ferry service to Southport
Myrtle Grove 13.5 21.7 NC 132 north (College Road) – Wilmington Southern terminus of NC 132
Wilmington 15 24 US 117 (Shipyard Boulevard) – Wilmington, State Port
18 29
US 76 east / US 17 Bus. north (3rd Street) – Wrightsville Beach, Downtown Wilmington		 East end of US 76 overlap, north end of US 17 Business overlap
19 31 Front Street Partial interchange
Brunswick
 21 34 US 17 / NC 133 south / US 74 / US 76 west – Bolivia, Southport, Whiteville South end of US 17/US 17 Business/NC 133 overlap, west end of US 74/76 overlap
New Hanover
 22 35 U.S.S. North Carolina Road/Battleship Road To the N.C. Battleship
24 39 US 74 east / NC 133 north – Wrightsville Beach, Hightsville East end of US 74 overlap, north end of NC 133 overlap
25.5 41.0 I-140 east / US 17 north – Hampstead, Topsail Island North end of US 17 overlap
Pender
 Long Creek 38.5 62.0 NC 210 – Rocky Point, Currie Also to Moores Creek National Battlefield on west NC 210
Malpass Corner 44 71 NC 11 south / NC 53 – Atkinson, Burgaw South end of NC 11 overlap
52 84 NC 11 north – Penderlea, Willard North end of NC 11 overlap
Sampson
 Harrells 60 97 NC 41 (Tomahawk Highway/Wallace Highway) – Tomahawk, Wallace
Delway 65 105 NC 903 (Magnolia-Lisbon Road) – Magnolia, Kenansville
Clinton 79 127
US 701 south (Garland Highway) / US 701 Bus. north (Sunset Boulevard) – Garland, Clinton		 South end of US 701 overlap
80 129 To NC 24 east (Tam Road) – Warsaw
81 130 NC 24 east (Southwest Boulevard) – Warsaw Southbound entrance and northbound exit, east end of NC 24 overlap
82 132 NC 24 west (Sunset Avenue) – Roseboro, Fayetteville West end of NC 24 overlap
83 134 US 701 north (Faircloth Freeway) – Newton Grove North end of US 701 overlap
95 153 NC 242 south (Salemburg Highway) – Salemburg, Roseboro South end of NC 242 overlap
Spivey's Corner 99 159 US 13 (Fayetteville Highway/Newton Grove Highway) – Fayetteville, Newton Grove
100 161 NC 242 north (Benson Highway) – Benson North end of NC 242 overlap
Harnett
 Dunn 109 175 I-95 / NC 55 east – Fayetteville, Benson, Newton Grove East end of NC 55 overlap
110 177 US 301 (Clinton Avenue) – Fayetteville, Benson
Erwin 114 183 NC 55 north / NC 82 south / NC 217 south (13th Street) – Erwin, Coats West end of NC 55 overlap
119 192 NC 27 east – Coats East end of NC 27 overlap; Harnett County Airport at intersection
Lillington 124 200 US 401 north (Cornelius Harnett Boulevard) / NC 210 north (Main Street) – Fuquay-Varina North end of US 401 and NC 210 overlap
125 201 US 401 south / NC 27 east / NC 210 south (Main Street) South end of US 401/NC 210 overlap, east end of NC 27 overlap
Lee
 Sanford 144 232 NC 87 south – Fayetteville South end of NC 87 overlap (Future Exit 143 on Sanford Bypass)
145 233 NC 42 east / NC 78 west (Main Street) – Fuquay-Varina East end of NC 42 overlap (Future Exit 144 on Sanford Bypass)
147 237
US 1 Bus. / NC 42 west (Carthage Street)		 West end of NC 42 overlap; also junction of U.S. Bike Route 1
149 240 US 1 / US 15 / US 501 / NC 87 north – Raleigh, Southern Pines North end of NC 87 overlap (Future Exit 149 on Sanford Bypass)
Chatham
 163 262 NC 902 – Pittsboro
168 270 168 Sam Fields Road – Siler City
Siler City 171 275 171 US 64 – Siler City, Pittsboro
174 280 174 Piney Grove Church Road
Randolph
 Staley 180 290 180 Old US Highway 421 – Liberty, Staley
Liberty 181 291 181 NC 49 – Liberty, Ramseur
184 296 Old Liberty Road – Liberty
Guilford
 Julian 190 306 NC 62 – High Point, Burlington
197 317 197 I-85 north to I-40 – Durham, Raleigh North end of I-85 overlap
US 421 overlaps with Interstate 85 (exits 126 to 121), Interstate 73 (exits 97 to 103), Interstate 40 (exits 212 to 206), and Interstate 40 Business (exits 16 to 1).
Forsyth
 Winston-Salem 234 377 238 I-40 / I-40 Bus. east – Winston-Salem, Statesville West end of Interstate 40 Business overlap
235 378 239 Jonestown Road
236 380 240 Peace Haven Road
Lewisville 238 383 242 Lewisville-Clemmons Road – Lewisville, Clemmons
240 386 244 Williams Road – Lewisville
242 389 246 Shallowford Road
Yadkin
 245 394 249 Dinkins Bottoms Road/Baltimore Road
247 398 251 Spear Bridge Road
249 401 253 Shacktown Road/Old Stage Road
252 406 256 Unifi Industrial Road
Yadkinville 253 407 257 US 601 (State Street) – Yadkinville, Mocksville
255 410 259 Reavis Road
Brooks Crossroads 259 417 263 US 21 – Jonesville
260 418 264 Asbury Church Road
262 422 265 I-77 – Elkin, Statesville, Charlotte Northbound is exit 265A, southbound is exit 265B
264 425 267 Windsor Road/Oak Grove Church Road
Wilkes
 267 430 270 Dennyville Road
269 433 272 To NC 268 (Clingman Road/Somers Road)
273 439 276 To NC 268 (Red, White, and Blue Road/Mathis Farm Road)
274 441 277 Windy Gap Road/Speedway Road
279 449 282
US 421 Bus. / NC 115 (Statesville Road) – North Wilkesboro, Statesville
Wilkesboro 282 454 285 Brushy Mountain Road – Wilkesboro
283 455 286A NC 16 south / NC 18 (Cherry Road) – Wilkesboro, Taylorsville, Lenoir South end of NC 16 overlap
283.5 456.2 NC 268 – Wilkesboro
284 457
US 421 Bus. (D Street) – North Wilkesboro
287 462 NC 16 north – Jefferson North end of NC 16 overlap
Watauga
 Deep Gap 304 489 Blue Ridge Parkway
305 491 US 221 north – West Jefferson North end of US 221 overlap
Boone 313 504 NC 194 north (Jefferson Road) – Todd North end of NC 194 overlap
314 505 US 221 south / NC 105 south (Highway 105 Extension) – Linville, Banner Elk South end of US 221 overlap
314.5 506.1 US 321 south (Hardin Street) – Blowing Rock South end of US 321 overlap
Vilas 320 515 NC 194 south – Valle Crucis South end of NC 194 overlap
Sugar Grove 321 517 US 321 north – Elizabethton North end of US 321 overlap
State line 328 528 US-421 north / SR-34 north – Mountain City
  • Concurrency terminus
  • Closed/former
  • HOV only
  • Incomplete access
  • Tolled/ETC
  • Unopened

Note – Exit numbers west of Winston-Salem are aligned when US 421 went north around Greensboro in late-1980s/early-1990s. As a result from realignments in Greensboro, the actual mileage vs. exit number mileage is off by an average of 3.5 miles (5.6 km).

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