U.S. Route 2

U.S. Route 2 (US 2) is an east–west U.S. Highway spanning 2,579 miles (4,150 km) across the northern continental United States. US 2 consists of two segments connected by various roadways in southern Canada. Unlike some routes, which are disconnected into segments because of encroaching Interstate Highways, the two portions of US 2 were designed to be separate in the original 1926 highway plan.

The western segment of US 2 has its western terminus at State Route 529 (Maple Street) in Everett, Washington and its eastern terminus at Interstate 75 in St. Ignace, Michigan. The eastern segment of US 2 has its western terminus at US 11 in Rouses Point, New York and its eastern terminus at Interstate 95 (I-95) in Houlton, Maine.

As its number indicates, it is the northernmost east–west U.S. Route in the country. It is the lowest primary-numbered east–west U.S. Route, whose numbers otherwise end in zero, and was so numbered to avoid a US 0.

Sections of US 2 in New England were once New England Route 15, part of the New England road marking system.