Upa or UPA may refer to:
In geography:
- Upa, Azerbaijan, a village in Khizi Rayon
- Upa, Estonia, village in Kaarma Parish, Saare County, Estonia
- Upa River, a river in Russia
- Úpa River, a river in the Czech Republic
In geopolitics:
- Uganda People's Army, a rebel group active from 1987-1992
- Ukrayins'ka Povstans'ka Armiya or Ukrainian Insurgent Army, a nationalist partisan organization during and after World War II
- Ulster Protestant Action
- United Progressive Alliance, a political coalition in power in the Indian government since 2004
In associations:
- Utenti Pubblicità Associati, the Italian Advertisers' Association, based in Milan, Italy
- United States Professional Poolplayers Association
- Universal Powerline Association, a body which promotes power line communication technology
- Usability Professionals' Association
In other uses:
- UPA (animation studio), an American animation studio
- Bridge (grappling) or upa, a move in Brazilian jiu jitsu designed to dislodge a mounted opponent
- Ultra Port Architecture, a computer bus developed by Sun Microsystems for its graphics workstations
- Uniform Partnership Act, a model statute proposed by the U.S. NCCUSL
- Unique Particle Attribution, a mechanism to prevent ambiguity in XML Schema
- University Preparatory Academy, a charter school in San Jose, California, USA
- Uralic Phonetic Alphabet, a notational system for the Uralic languages
- Urokinase or uPA, a serine protease enzyme
- Upa, a character in Bio Miracle Bokutte Upa
- Urban Protection Agency, a fictional organisation in Project Eden