Uihlein may refer to:
- August Uihlein (1842-1911), German-born American businessman.
- Joseph E. Uihlein (1875-1968), American businessman.
- David Vogel Uihlein, Sr. (1920-2010), American heir and businessman.
- David Vogel Uihlein, Jr., American heir, businessman and conservative philanthropist.
- Lynde Bradley Uihlein, American heiress and liberal philanthropist.
- Robert Uihlein, Jr. (1916–1976), American businessman.
- Wally Uihlein.
- Uihlein Soccer Park
- Herman Uihlein House