UHRF1

UHRF1

Identifiers Symbols UHRF1; ICBP90; Np95; RNF106; hNP95; hUHRF1 External IDs OMIM: 607990 MGI: 1338889 HomoloGene: 7866 GeneCards: UHRF1 Gene EC number 6.3.2.19

Gene Ontology
Molecular function	• core promoter proximal region sequence-specific DNA binding • sequence-specific DNA binding transcription factor activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding • methyl-CpG binding • nucleosomal histone binding • methylated histone residue binding • histone binding • identical protein binding • hemi-methylated DNA-binding
Cellular component	• nuclear chromatin • euchromatin • heterochromatin • nucleus • replication fork • nuclear matrix
Biological process	• negative regulation of transcription from RNA polymerase II promoter • DNA repair • transcription, DNA-dependent • cell cycle • cell proliferation • maintenance of DNA methylation • histone monoubiquitination • histone ubiquitination • positive regulation of cellular protein metabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of transcription from RNA polymerase II promoter • protein autoubiquitination • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 29128 18140 Ensembl ENSG00000034063 ENSMUSG00000001228 UniProt Q96T88 Q8VDF2 RefSeq (mRNA) NM_001048201 NM_001111078 RefSeq (protein) NP_001041666 NP_001104548 Location (UCSC) Chr 19:
4.91 – 4.96 Mb Chr 17:
56.3 – 56.32 Mb PubMed search

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene.