Ubiquitin Carboxyl-terminal Hydrolase L5

Identifiers Symbols UCHL5; CGI-70; INO80R; UCH-L5; UCH37 External IDs OMIM: 610667 MGI: 1914848 HomoloGene: 9326 GeneCards: UCHL5 Gene EC number 3.4.19.12

Gene Ontology
Molecular function	• ubiquitin thiolesterase activity • ubiquitin-specific protease activity • endopeptidase inhibitor activity • protein binding • omega peptidase activity • proteasome binding
Cellular component	• proteasome complex • nucleus • cytoplasm • cytosol • Ino80 complex
Biological process	• DNA repair • DNA recombination • transcription, DNA-dependent • regulation of transcription, DNA-dependent • ubiquitin-dependent protein catabolic process • transforming growth factor beta receptor signaling pathway • negative regulation of endopeptidase activity • protein deubiquitination • lateral ventricle development • negative regulation of transforming growth factor beta receptor signaling pathway • midbrain development • forebrain morphogenesis • regulation of proteasomal protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51377 56207 Ensembl ENSG00000116750 ENSMUSG00000018189 UniProt Q9Y5K5 Q9WUP7 RefSeq (mRNA) NM_001199261 NM_001159866 RefSeq (protein) NP_001186190 NP_001153338 Location (UCSC) Chr 1:
192.98 – 193.03 Mb Chr 1:
143.78 – 143.81 Mb PubMed search

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.