Twombly may refer to:
In people:
- Carol Twombly, an American calligrapher
- Cy Twombly (1928–2011), an American abstract artist
- Kris Lev-Twombly (b. 1972), an advocate for criminal justice reform
- Hamilton McKnown Twombly, railroad tycoon, owner of Vinland Estate
In places:
- Twombly Ridge, Maine, an unorganized area in the United States
In other uses:
- Twombly (automobile), an automobile manufactured between 1910 and 1911
- Twombly (cyclecar), an American automobile manufactured between 1913 and 1915
- Bell Atlantic Corp. v. Twombly, a United States Supreme Court case
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