Twitty may refer to:
- Twitty City, former name of Trinity Music City, entertainment complex in Hendersonville, Tennessee, United States, home of Conway Twitty
- Victor Twitty (1901-1967), American biologist
- Beth Holloway-Twitty (born c. 1961), crime victim advocate and mother of missing student Natalee Holloway
- Conway Twitty (1933–1993), American country music artist
- Howard Twitty (born 1949), American professional golfer
- Jeff Twitty (born 1957), Major League Baseball pitcher
- Stephen Twitty (born 1963), United States Army Colonel