Tumor M2-PK is a synonym for the dimeric form of the pyruvate kinase isoenzyme type M2 (PKM2), a key enzyme within tumor metabolism. Tumor M2-PK can be elevated in many tumor types, rather than being an organ-specific tumor marker such as PSA. Increased stool (fecal) levels are being investigated as a method of screening for colorectal tumors (= bowel cancer), and EDTA plasma levels are undergoing testing for possible application in the follow-up of various cancers.
Sandwich ELISA’s based on two monoclonal antibodies which specifically recognize Tumor M2-PK (the dimeric form of M2-PK) are available for the quantification of Tumor M2-PK in stool and EDTA-plasma samples respectively. As a biomarker, the amount of Tumor M2-PK in stool and EDTA-plasma reflects the specific metabolic status of the tumors.
Read more about Tumor M2-PK: Early Detection of Colorectal Tumors and Polyps, Cancer Follow-up, Tetrameric and Dimeric PKM2, Mutations, Potential Multi-functional Protein, See Also