Tsuji (辻, Tsuji?) is a Japanese surname meaning 'crossroad':
- Ayano Tsuji (1978-) is a pop singer
- Chie Tsuji (born 1969), Japanese volleyball player
- Hatsuhiko Tsuji (1958-) was a professional baseball
- Hitonari Tsuji (1959-) is a Japanese writer and composer
- Jiro Tsuji is a Japanese chemist (Tsuji Trost reaction)
- Jun Tsuji (1884 –1944) was a Japanese author
- Kunio Tsuji (1925–1999) was a Japanese author
- Masaki Tsuji (1932) is a Japanese writer
- Masanobu Tsuji(1902–1961) was a Japanese officer
- Nozomi Tsuji (1987-) is a Japanese pop singer
- Ryuu Tsuji, a fictional character from Special A.
- Shinpachi Tsuji (1956-) is a Japanese voice actor
- Shintaro Tsuji (1927) is a Japanese business man
- Yasuhiro Tsuji (1955-) is a Japanese politician
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