TSN (gene)

TSN (gene)

Identifiers Symbols TSN; BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN External IDs OMIM: 600575 MGI: 109263 HomoloGene: 3397 GeneCards: TSN Gene

Gene Ontology
Molecular function	• DNA binding • mRNA binding • endonuclease activity • protein binding • sequence-specific DNA binding
Cellular component	• nucleus • cytoplasm
Biological process	• DNA recombination
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7247 22099 Ensembl ENSG00000211460 ENSMUSG00000026374 UniProt Q15631 Q62348 RefSeq (mRNA) NM_001261401 NM_011650 RefSeq (protein) NP_001248330 NP_035780 Location (UCSC) Chr 2:
122.49 – 122.53 Mb Chr 1:
118.3 – 118.31 Mb PubMed search

Translin is a protein that in humans is encoded by the TSN gene.

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.