The acronym TSM can stand for:
- Taiwan Semiconductor Manufacturing Company, a semiconductor foundry, headquartered in Taiwan.
- IBM Tivoli Storage Manager, an enterprise backup software product from IBM.
- IBM Tivoli Storage Manager FastBack a continuous data protection and recovery management platform for Windows servers from IBM
- Teaching-suggestion-motivation, a concept in United States patent law.
- The Simpsons Movie, a 2007 film.
- The Suicide Machines, a punk band.
- Trinity School for Ministry, an evangelical seminary in the Anglican tradition, serving The Episcopal Church and the broader Anglican Communion.
- Tribunal Superior Militar (Superior Military Court), a federal court in Brazil.
- Trapezoidal Shadow Map
- Toy Story Mania!, a video game
- Troye Sivan Mellet, boy soprano singer from Western Australia
- TRADOC System Manager
- Team Service Management, a management framework.
- The Sims Medieval, a 2011 simulation video game published by Electronic Arts.
- Trusted service manager, a business role in the mobile payment environment.
- Team SoloMid, a website and organization which sponsors a professional team for the video game League of Legends.