TSG can refer to:
- TSG Consumer Partners, a private equity firm formerly known as The Shansby Group
- TSG Solutions, Inc, aka Tactical Survey Group, a company that specializes in Digital Mapping, Information Technology and Risk Assessments
- Technology Solutions Group, former name of HP Enterprise Business, a part of Hewlett-Packard
- Territorial Support Group, a special response unit of London's Metropolitan Police Service
- Traditional Speciality Guaranteed, one of three Protected Geographical Status classifications used in European Union Law to protect regional foods
- Sabre Holdings (via its former ticker symbol on the New York Stock Exchange)
- The Smoking Gun, a website
- TSG Group aka The SCO Group, a software company
- Tumor suppressor genes, which prevent cellular damage from leading to cancer
- TheSpeedGamers, a charity group that plays speed runs of games to raise money for charity organizations
- There She Goes, a song by Lee Mavers recorded by The La's and covered by Sixpence None the Richer, among others.
- TSG, Test Signal Generator function in UHF audio-video RF modulators
- Tungsten Shield Group, a company that specializes in e-learning in the pharmaceutical industry.