Permeability and Activation
The relative permeability of calcium and magnesium varies widely among TRPM channels.
- TRPM4 and TRPM5 are impermeable to calcium.
- TRPM3, TRPM6 and TRPM7 are highly permeable to both calcium and magnesium.
The mechanism of activation also varies greatly among TRPM channels.
- TRPM2 is activated by ADP-ribose Adenosine 5'-diphosphoribose and functions as a sensor of redox status in cells.
- TRPM4 and TRPM5 are activated by intracellular calcium.
- TRPM8, conversely, can be activated by low temperatures, menthol, eucalyptol and icilin.
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