Pharmacokinetics
Troxipide is well absorbed throughout the gastrointestinal tract with a relative bioavailability of 99.6%. At any time, a mean concentration of 5.3- 8.9 µg of troxipide is present per gram of tissue, which is capable of inhibiting the chemotactic migration and superoxide generation in the gastric mucosa. Thus, even 3 hrs after attaining peak serum levels, troxipide is found in therapeutically active concentrations in the small intestine, liver and stomach. The elimination half-life of troxipide is 7.5 hours, and is mainly excreted in urine (96% as metabolites).
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