Role in Disease
TrkA was originally cloned from a colon tumor; the cancer occurred via a translocation, which resulted in the activation of the TrkA kinase domain. However, TrkA itself does not appear to be an oncogene.
In one study, a total absence of TrkA receptor was found in keratoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.
Read more about this topic: Trk A Receptor
Famous quotes containing the words role in, role and/or disease:
“My role in society, or any artist or poet’s role, is to try and express what we all feel. Not to tell people how to feel. Not as a preacher, not as a leader, but as a reflection of us all.”
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“John F. Kennedy was the victim of the hate that was a part of our country. It is a disease that occupies the minds of the few but brings danger to the many.”
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