Interactions
TrkA has been shown to interact with:
- Abl gene.
- FRS2,
- Grb2,
- MATK,
- NGFB,
- PLCG1,
- RICS,
- SQSTM1,
- SH2B1,
- SH2B2, and
- SHC1.
Small molecules such as amitriptyline and gambogic acid derivatives have been claimed to activate TrkA. Amitriptyline activates TrkA and facilitate the heterodimerisation of TrkA and TrkB in the absence of NGF. Binding of Amitriptyline to TrkA occurs to the Leucine Rich Region (LRR) of the extracellular domain of the receptor, which is distinct from the NGF binding site. Amitryptiline possess neurotrophic activity both in-vitro and in-vivo (mouse model). Gambogic Amide, a derivative of Gambogic acid, selectively activates TrkA (but not TrkB and TrkC) both in-vitro and in-vivo by interacting with the cytoplasmic juxtamembrane domain of TrkA.
Read more about this topic: Trk A Receptor
Famous quotes containing the word interactions:
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