Trk A Receptor
| Gene Ontology | |
|---|---|
| Molecular function | • transmembrane receptor protein tyrosine kinase activity • neurotrophin p75 receptor binding • protein binding • ATP binding • nerve growth factor receptor activity • protein homodimerization activity • neurotrophin binding • ephrin receptor binding • nerve growth factor binding |
| Cellular component | • endosome • plasma membrane • integral to plasma membrane • cell surface • axon • dendrite • cytoplasmic vesicle • early endosome membrane • neuronal cell body |
| Biological process | • activation of MAPKK activity • protein phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • activation of adenylate cyclase activity • activation of phospholipase C activity • small GTPase mediated signal transduction • Ras protein signal transduction • axon guidance • aging • learning or memory • negative regulation of cell proliferation • response to radiation • developmental programmed cell death • positive regulation of neuron projection development • response to activity • olfactory nerve development • B cell differentiation • response to nutrient levels • positive regulation of Ras GTPase activity • mechanoreceptor differentiation • response to drug • positive regulation of programmed cell death • negative regulation of neuron apoptotic process • response to ethanol • positive regulation of angiogenesis • positive regulation of Ras protein signal transduction • protein autophosphorylation • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • sympathetic nervous system development • response to axon injury • detection of temperature stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception of pain • positive regulation of NF-kappaB transcription factor activity • response to hydrostatic pressure • response to electrical stimulus • positive regulation of synaptic transmission, glutamatergic • Sertoli cell development • axonogenesis involved in innervation • positive regulation of ERK1 and ERK2 cascade • cellular response to nicotine |
| Sources: Amigo / QuickGO | |
156.79 – 156.85 Mb
87.78 – 87.8 Mb
High affinity nerve growth factor receptor also known as neurotrophic tyrosine kinase receptor type 1 or TRK1-transforming tyrosine kinase protein or Trk-A is a protein that in humans is encoded by the NTRK1 gene.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Read more about Trk A Receptor: Function, Family Members, The Low Affinity Nerve Growth Factor Receptor, Role in Disease, Regulation of TrkA, Interactions
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