Adverse Effects
The common side effects are related to the anticholinergic effect on parasympathetic postsynaptic receptors: dry mouth, throat, and nasal passages in overdose cases progressing to impaired speech, thirst, blurred vision, sensitivity to light, constipation, difficulty urinating, and tachycardia. Other effects of overdose include flushing and fever, as well as excitement, restlessness, hallucinations, or delirium. These side effects are commonly observed with oral or parenteral uses of the drug and generally not with topical ophthalmic use.
Use in scuba diving to prevent sea sickness has led to the discovery of another side effect. In deep water, below 50–60 feet, some divers have reported pain in the eyes that subsides quickly if the diver ascends to a depth of 40 feet or less. Mydriatics can precipitate an attack of glaucoma in susceptible patients, so the medication should be used with extra caution among divers who intend to go below 50 feet.
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