Chemistry
Trifluoperazine (2-trifluoromethyl-10-phenothazine) is synthesized in the manner described already for prochlorperazine, alkylation is performed using 2-trifluoromethylphenothazin-4-methyl-1-piperazinylpropylchloride as the substrate.
- Craig, P.; Nodiff, E.; Lafferty, J.; Ullyot, G. (1957). Journal of Organic Chemistry 22 (6): 709. doi:10.1021/jo01357a618. edit
- G.E. Ullyot, U.S. Patent 2,921,069 (1960).
- Sharma, H.; Banerjee, S.; Sharma, V.; Mital, R. (1968). "Phenothiazines Exhibiting Lesser Extraparamidal Manifestations". Journal of Medicinal Chemistry 11 (6): 1244. doi:10.1021/jm00312a600. PMID 5680054. edit
- P.N. Craig, G.E. Ullyot, DE 1165034 (1956).
- B.H. Chung, F. Zimalkowski, Arch. Pharm., 317, 323 (1984).
Read more about this topic: Trifluoperazine
Famous quotes containing the word chemistry:
“...some sort of false logic has crept into our schools, for the people whom I have seen doing housework or cooking know nothing of botany or chemistry, and the people who know botany and chemistry do not cook or sweep. The conclusion seems to be, if one knows chemistry she must not cook or do housework.”
—Ellen Henrietta Swallow Richards (1842–1911)
“For me chemistry represented an indefinite cloud of future potentialities which enveloped my life to come in black volutes torn by fiery flashes, like those which had hidden Mount Sinai. Like Moses, from that cloud I expected my law, the principle of order in me, around me, and in the world.... I would watch the buds swell in spring, the mica glint in the granite, my own hands, and I would say to myself: “I will understand this, too, I will understand everything.””
—Primo Levi (1919–1987)
“The chemistry of dissatisfaction is as the chemistry of some marvelously potent tar. In it are the building stones of explosives, stimulants, poisons, opiates, perfumes and stenches.”
—Eric Hoffer (1902–1983)