Sleeping Beauty Transposase
The Sleeping Beauty (SB) transpose is the recombinase that drives the Sleeping Beauty transposon system. SB transposase belongs to the DD family of transposases, which in turn belong to a large superfamily of polynucleotidyl transferases that includes RNase H, RuvC Holliday resolvase, RAG proteins, and retroviral integrases. The SB system is used primarily in vertebrate animals for gene transfer, including gene therapy, and gene discovery The recently engineered SB100X is an especially powerful enzyme that directs the highest levels of transposon integration yet developed
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