Rejection Detection
Diagnosis of acute rejection relies on clinical data—patient signs and symptoms—but also calls on laboratory data such as tissue biopsy. The laboratory pathologist generally seeks three main histological signs: (1) infiltrating T cells, perhaps accompanied by infiltrating eosinophils, plasma cells, and neutrophils, particularly in telltale ratios, (2) structural compromise of tissue anatomy, varying by tissue type transplanted, and (3) injury to blood vessels. Tissue biopsy is restricted, however, by sampling limitations and risks/complications of the invasive procedure. Cellular magnetic resonance imaging (MRI) of immune cells radiolabeled in vivo might offer noninvasive testing.
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Famous quotes containing the word rejection:
“He began therefore to invest the fortress of my heart by a circumvallation of distant bows and respectful looks; he then entrenched his forces in the deep caution of never uttering an unguarded word or syllable. His designs being yet covered, he played off from several quarters a large battery of compliments. But here he found a repulse from the enemy by an absolute rejection of such fulsome praise, and this forced him back again close into his former trenches.”
—Sarah Fielding (1710–1768)