The TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multi-protein complex consisting of the RNA helicase Mtr4, a poly(A) polymerase (PAP) (either Trf4 or Trf5) and a zinc knuckle protein (either Air1 or Air2). The TRAMP complex interacts with the exosome complex in the nucleus of eukaryotic cells and is involved in the 3' end processing of ribosomal RNA and snoRNAs.
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“In the small circle of pain within the skull
You still shall tramp and tread one endless round
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Weaving a fiction which unravels as you weave,
Pacing forever in the hell of make-believe
Which never is belief: this is your fate on earth
And we must think no further of you.”
—T.S. (Thomas Stearns)
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—Walter Lippmann (1889–1974)