Trafficking may refer to:
- Ad trafficking, the process of supplying campaign creative materials and tracking links to publishers through an ad serving platform
- Arms trafficking, the smuggling of contraband weapons or ammunition
- Human trafficking, the tricking or luring of people away from their homeland to work under exploitative conditions elsewhere
- Drug trafficking, the cultivation, manufacture, distribution and sale of illegal drugs
- Protein trafficking, the mechanism by which a cell transports proteins to appropriate positions