Topo or TOPO may refer to:
- Topo (Azores), a civil parish in the municipality of Calheta, in the Portuguese archipelago of the Azores
- Topo (climbing), in climbing, a guide for a crag or climbing area
- Topo (robot), a robot aimed at the consumer and educational market, and produced during the 1980s by Androbot
- Topography or topographic map
- Trioctylphosphine oxide, abbreviated as TOPO
- Los Topos, a 1970s Californian theatre group named after the Spanish for mole (Topo), one of whose members was also known as Topo
- Topo (DC Comics), a fictional character in Aquaman series
- TOPO Cloning, in genetics
- TopoTarget, "TOPO" being this company's trading symbol on the Copenhagen Stock Exchange
- Topos de Tlatelolco an earthquake and natural disaster search and rescue squad from Mexico
- Topo Gigio, a popular Italian puppet character, made famous by appearances on "The Ed Sullivan Show"
El Topo might refer to:
- El Topo, 1970 Mexican film.
- El Topo (Puerto Rican singer/songwriter), stage name for Antonio Caban Vale.