Tolbutamide - Side Effects

Side Effects

  1. Hypoglycemia
  2. Weight gain
  3. Hypersensitivity- Cross-allergicity with sulfonamide
  4. Drug Interactions (especially first generation drugs): Increased hypoglycemia with cimetidine, insulin, salicylates, sulfonamides

Salicylates displace tolbutamide from its binding site on plasma binding proteins which lead to increase in free tolbutamide concentration and thus hypoglycemic shock.

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