Side Effects
- Hypoglycemia
- Weight gain
- Hypersensitivity- Cross-allergicity with sulfonamide
- Drug Interactions (especially first generation drugs): Increased hypoglycemia with cimetidine, insulin, salicylates, sulfonamides
Salicylates displace tolbutamide from its binding site on plasma binding proteins which lead to increase in free tolbutamide concentration and thus hypoglycemic shock.
Read more about this topic: Tolbutamide
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