ERG Gene Fusion
TMPRSS2 protein's function in prostate carcinogenesis relies on overexpression of ETS transcription factors, such as ERG and ETV1 through gene fusion. TMPRSS2-ERG fusion gene is the most frequent, present in 40% - 80% of prostate cancers in humans. ERG overexpression contributes to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling.
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Famous quotes containing the word fusion:
“Sadism and masochism, in Freud’s final formulation, are fusions of Eros and the destructive instincts. Sadism represents a fusion of the erotic instincts and the destructive instincts directed outwards, in which the destructiveness has the character of aggressiveness. Masochism represents the fusion of the erotic instincts and the destructive instincts turned against oneself, the aim of the latter being self-destruction.”
—Patrick Mullahy (b. 1912)