TMD may refer to:
- Medicine and science
- Temporomandibular joint disorder
- Transmembrane domain
- Tuned mass damper
- Other
- Team Deathmatch
- The Medic Droid, a band
- Theater Missile Defense, a land- or ship-based missile defense initiative developed by the United States armed forces under the Clinton administration
- Thorn Microwave Devices Ltd.
- Tip-Magnetic Driving
- Tongue Me Deeply
- Toshiba Matsushita Display Technology Co., Ltd.
- Traction Maintenance Depot
- Trade Marks Directive
- Truly Madly Deeply, a song by Savage Garden
- An industry and television listings abbreviation for the American television network Telemundo.
- Title meta-database
- A Chinese internet abbreviation for the swear word 他妈的 tamade "of his mother".