TMC may stand for:
- Tennis Masters Cup, a part of the ATP World Tour Finals
- Thomas & Mack Center, an indoor arena on the campus of the University of Nevada, Las Vegas opened in 1983.
- Timaru Mongrel Club, Timaru, South Canterbury, New Zealand
- Titanium Matrix Composites
- Total Music Communication, a Japanese music collaboration between Rip Slyme — a Japanese hip-hop group — and others
- Traffic Message Channel, a technology for delivering traffic and travel information to drivers
- Transportation Materiel Command, a unit of the United States Army until 1962
- Trapeziometacarpal joint, see Carpometacarpal joint#Thumb
- Thomas More College, a leading private school in South Africa
- tmc is the measure of volume of water, meaning thousand million cubic ft of water. Usually refers to volume of water in storage dams. e.g. 10 tmc of water.
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