Tissue Factor - Structure

Structure

The protein structure of TF consists of three domains:

  1. a domain which is located outside the cell, this domain binds factor VIIa. The binding of VIIa to TF occurs via protein-protein interactions by both molecules.
    1. Factor VIIa is a protein which consists of several domains. One of these domains, the carboxylated GLA domain, binds in the presence of calcium to negatively charged phospholipids. Binding of VIIa to negatively charged phospholipids greatly enhances the protein-protein binding of VIIa to TF.
  2. a domain which crosses the hydrophobic membrane.
  3. a domain of 21 amino acids length inside the cell which is involved in the signaling function of TF.

Read more about this topic:  Tissue Factor

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