Thymine-DNA Glycosylase

Thymine-DNA Glycosylase

Identifiers Symbol TDG External IDs OMIM: 601423 HomoloGene: 2415 GeneCards: TDG Gene EC number 3.2.2.29

Gene Ontology
Molecular function	• RNA polymerase II transcription cofactor activity • damaged DNA binding • double-stranded DNA binding • protein binding • pyrimidine-specific mismatch base pair DNA N-glycosylase activity • DNA N-glycosylase activity • mismatched DNA binding • SUMO binding • protein homodimerization activity • structure-specific DNA binding
Cellular component	• nucleus • nucleoplasm • PML body
Biological process	• negative regulation of transcription from RNA polymerase II promoter • DNA repair • base-excision repair • base-excision repair, AP site formation • mismatch repair • embryo development • chromatin modification • negative regulation of protein binding • negative regulation of chromatin binding • regulation of gene expression, epigenetic • depyrimidination • DNA demethylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6996 21665 Ensembl ENSG00000139372 ENSMUSG00000034674 UniProt Q13569 P56581 RefSeq (mRNA) NM_001008411 NM_011561 RefSeq (protein) NP_003202 NP_035691 Location (UCSC) Chr 12:
104.36 – 104.38 Mb Chr 10:
82.63 – 82.65 Mb PubMed search

G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein.