Principles
Formation of blood clots lies at the basis of a number of serious diseases (see below). By breaking down the clot, the disease process can be arrested, or the complications reduced. While other anticoagulants (such as heparin) decrease the "growth" of a clot, thrombolytic agents actively reduce the size of the clot.
Most thrombolytic agents work by activating the enzyme plasminogen, which clears the cross-linked fibrin mesh (the backbone of a clot). This makes the clot soluble and subject to further proteolysis by other enzymes, and restores blood flow over occluded blood vessels.
Read more about this topic: Thrombolysis
Famous quotes containing the word principles:
“It is a life-and-death conflict between all those grand, universal, man-respecting principles which we call by the comprehensive term democracy, and all those partial, person-respecting, class-favoring elements which we group together under that silver-slippered word aristocracy. If this war does not mean that, it means nothing.”
—Antoinette Brown Blackwell (1825–1921)
“I am not one of those who have the least anxiety about the triumph of the principles I have stood for. I have seen fools resist Providence before, and I have seen their destruction, as will come upon these again, utter destruction and contempt. That we shall prevail is as sure as that God reigns.”
—Woodrow Wilson (1856–1924)
“The same principles which at first view lead to skepticism, pursued to a certain point, bring men back to common sense.”
—George Berkeley (1685–1753)