Presence in Human and Mouse
The enzyme is synthesized and functional in mice.
Humans also have the remnants of the gene, coding this enzyme (GLY1), however it is damaged by past mutations and inactive. Human gene contains two single nucleotide deletions causing frameshifts and premature stop codons. Also, the encoded protein would not be active anyway due mutations in other highly conserved regions. Human gene is no longer transcribed into RNA.
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Famous quotes containing the words presence, human and/or mouse:
“He who is ready to despair in solitary peril, plucks up a heart in the presence of another. In a plurality of comrades is much countenance and consolation.”
—Herman Melville (1819–1891)
“I am secretly afraid of animals.... I think it is because of the usness in their eyes, with the underlying not-usness which belies it, and is so tragic a reminder of the lost age when we human beings branched off and left them: left them to eternal inarticulateness and slavery. Why? their eyes seem to ask us.”
—Edith Wharton (1862–1937)
“An epicure dining at Cree
Found a rather large mouse in his stew.
Said the waiter, “Don’t shout,
Or wave it about,
Or the rest will be wanting one too.””
—Anonymous.