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- Thomas C. Butler, American scientist of infectious diseases
- Thomas Adair Butler (1836–1901), English recipient of the Victoria Cross
- Thomas Harrison Butler (1871–1945), British ophthalmologist and amateur boat designer
- Tom Butler (bishop) (born 1940), Bishop of Southwark, England
- Tom Butler (actor) (born 1951), Canadian actor
- Tommy Butler (1915–1977), detective who investigated the 1963 Great Train Robbery
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