Thermal Analysis of Pharma Materials
DSC,TG/DTA and TG/DTA-IR are often used for characterisation of pharma materials. DSC, alone or in combination with hot-stage microscopy, is able to differentiate between different polymorphic structures and, by using different heating rates, can investigate the transformations which occur during the polymorphic transformation. By using appropriate heating rates, polymorphic purity can be determined, and can involve heating rates up to 750°C/min. TGA is often used to measure residual solvents and moisture, but can also be used to determine solubility of pharma materials in solvents. Analysis of pharma materials is probably the largest area of application for thermal analysis.
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