- John Joseph Abercrombie (1798–1877), Civil War general
- Timothy Shay Arthur (1809–1885), author, founder of Arthur's Home Magazine
- Hartman Bache (1798–1872), Civil War Union brevet brigadier general
- Anthony Joseph Drexel Biddle, Sr. (1875–1948), author, adventurer, the man upon whom the play and film The Happiest Millionaire were based
- Anthony Joseph Drexel Biddle, Jr. (1897–1961), diplomat (cenotaph)
- David B. Birney (1825–1864), Civil War Union major general
- Sylvester Bonnaffon, Jr. (1844–1922), Civil War Medal of Honor recipient
- Benjamin Harris Brewster (1816–1888), presidential cabinet secretary
- William Christian Bullitt (1891–1967), diplomat, journalist, and novelist
- James Hepburn Campbell (1820–1895), U.S. congressman
- Joseph A. Campbell (1817–1900), businessman, founder of Campbell Soup Company
- Edward Coles (1786–1868), 2nd governor of Illinois, private secretary to Presidents Thomas Jefferson and James Madison
- Elliott Cresson (1796–1854), philanthropist
- Paul Philippe Cret (1876–1945), architect, designed the Woodlands' main gate
- Thomas Cripps (1840–1906), Civil War Medal of Honor recipient
- George H. Crosman (1799–1882), Civil War brevet major general
- Jacob Mendes Da Costa (1833–1900), surgeon
- Francis Martin Drexel (1792–1863), Philadelphia banker, progenitor of the Drexel banking dynasty
|
- Anthony Joseph Drexel (1826–1893), founder of Drexel University
- Joseph William Drexel (1833–1888), banker, trustee of the Metropolitan Museum of Art and the U.S. National Academy of Sciences, and director of the Metropolitan Opera house
- Francis Anthony Drexel (1824–1885), banker, father of Saint Katharine Drexel
- Susan Eakins (1851–1938), artist, wife of Thomas Eakins
- Thomas Eakins (1844–1916), artist
- John Ely (1816–1869), Civil War Union brevet major general
- Thomas W. Evans (1823–1897), dentist
- Wilson Eyre (1858–1944), architect
- Clement Finley (1797–1879), Civil War Union brevet brigadier general
- Alice Fisher (1839–1888), nursing pioneer at the former Philadelphia General Hospital
- Sidney George Fisher (1809–1871) lawyer, farmer, political essayist
- John Fraser (1825–1906), architect
- Samuel David Gross (1805–1884), medical pioneer
- James Gwyn (1828–1906), Civil War Union brevet major-general
- Ferdinand Vandeveer Hayden (1829–1887), geologist
- Charles Herring (1829–1889), Civil War Union brevet brigadier general
- Edward W. Heston (1745–1824), PA state senator and Revolutionary War colonel, founder and namesake of Hestonville
- Eliza Hewitt (1851–1920), hymn composer
- Henry Horn (1786–1862), U.S. congressman
- Charles Jared Ingersoll (1782–1862), U.S. congressman
|
- William Williams Keen (1837–1932), first U.S. brain surgeon
- John Lane (1831–1903), Civil War Union brevet brigadier general
- James Barton Longacre (1794–1869), engraver
- Silas Weir Mitchell (1829–1914), physician and writer
- Samuel Moore (1774–1861), U.S. congressman
- Anna Claypoole Peale (1791–1878), American miniature painter, daughter of James Peale
- Rembrandt Peale (1778–1860), artist
- Eli Kirk Price (1797–1884), lawyer, state senator
- Eli Kirk Price II (1860–1933), lawyer, art patron
- Lewis Redner (1831–1908), organist, composer, wrote the music for Phillips Brooks's poem "O Little Town of Bethlehem"
- William Rush (1756–1833), sculptor
- John Scott (1824–1896), U.S. senator
- Thomas Alexander Scott (1823–1881), president of the Pennsylvania Railroad
- Jessie Willcox Smith (1863–1935), illustrator
- Charles Stewart (1778–1869), naval officer
- Frank R. Stockton (1834–1902), author of "The Lady or the Tiger?" and other tales
- Edward T. Stotesbury (1849–1938), prominent partner at J.P. Morgan & Co. and its Philadelphia affiliate Drexel & Co. for over 55 years
- William Moseley Swain (1809–1868), journalist
- James Thompson (1806–1874), U.S. congressman
- John Edgar Thomson (1808–1874), civil engineer, railroad executive and industrialist
- Rufus Welch (1800–1855), circus impresario
- Asa Whitney (1797–1872), railroad magnate
- Alan Wood, Jr., U.S. congressman
- Horatio Curtis Wood (1841–1920), physician
|