Cast
- Eric Bana as Henry DeTamble, a Chicago librarian
- Rachel McAdams as Clare DeTamble (née Abshire), an artist
- Ron Livingston as Gomez, Clare and Henry's friend and Charisse's boyfriend
- Jane McLean as Charisse, Clare's best friend and roommate
- Stephen Tobolowsky as Dr. David Kendrick
- Arliss Howard as Richard DeTamble, Henry's father, a professional violinist
- Brooklynn Proulx as Young Clare Abshire (ages 6 and 8)
- Alex Ferris as Young Henry DeTamble (age 6)
- Hailey McCann (ages 9 and 10) and Tatum McCann (ages 4 and 5) as Alba DeTamble, Henry and Clare's daughter
- Michelle Nolden as Annette DeTamble, Henry's mother
- Maggie Castle as Alicia Abshire, Clare's younger sister
- Fiona Reid as Lucille Abshire, Clare's mother
- Philip Craig as Philip Abshire, Clare's father
- Brian Bisson as Mark Abshire, Clare's brother
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