The Texas Heart Institute - Research

Research

The Stem Cell Center of the Texas Heart Institute was first in the United States to receive FDA approval for an adult stem cell clinical trial to treat patients with advanced heart failure. In addition, the Texas Heart Institute was one of five centers selected by the National Institutes of Health to study stem cell treatments for patients with cardiovascular disease. The National Heart, Lung, and Blood Institute has provided a $33.7 million to support these centers in a new national consortium called the Cardiovascular Cell Therapy Research Network.

Physician scientists at the Texas Heart Institute have amassed the world’s greatest experience in the development and use of ventricular assist devices (VADs) to sustain the failing circulation in patients with severe heart failure. More than a dozen different VADs are being studied in clinical trials conducted by the Center for Cardiac Support at the Texas Heart Institute, and more are under development in preclinical studies. A key area of research in the field of VADs is the concept of heart failure “remission,” or the use of a VAD to support a patient’s heart, thus giving the heart time to heal and recover normal function. Over the last three years, seven patients supported long term with a HeartMate II VAD have achieved remission, allowing for the removal of their devices. Researchers are also working on the development of a small total artificial heart that would deliver blood by continuous flow rather than pulsation.

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