Notable Guest Stars
Further information: List of The Practice awards and nominationsThe series holds the Emmy Award record for most wins in the Guest Actor and Actress categories for a single series, as well as most nominations in those categories. Emmys went to John Larroquette, Edward Herrmann, James Whitmore, Beah Richards, Michael Emerson, Charles S. Dutton, Alfre Woodard, Sharon Stone, and William Shatner. In addition, Tony Danza, Paul Dooley, Henry Winkler, Marlee Matlin, Rene Auberjonois, and Betty White were nominated but did not win. Larroquette, who won for his guest appearance during the second season, was nominated again for an episode from the sixth season, but did not win. The series won the Outstanding Guest Actor in a Drama Series for five consecutive years (from 1998–2002).
- Lake Bell as Sally Heep (precursor to Boston Legal)
- William Shatner as Denny Crane (precursor to Boston Legal)
- Andre Braugher as Ben Gideon ("Gideon's Crossover", Season 5 – crossover with Gideon's Crossing)
- Chi McBride as Steven Harper ("The Day After", Season 5 – crossover with Boston Public)
- Calista Flockhart as Ally McBeal ("Axe Murderer", Season 2 – crossover with Ally McBeal)
- John C. McGinley as Leonard Good
- Tony Danza as Tommy Silva
- Bruce Davison as Scott Wallace
- Patrick Dempsey as Paul Stewart
- Charles Durning as Stephen Donnell
- Charles S. Dutton as Leonard Marshall
- Alfre Woodard as Denise Freeman
- Anthony Heald as Wallace Cooper
- John Larroquette as Joey Heric
- Marlee Matlin as Sally Berg
- Chris O'Donnell as Brad Stanfield
- Vincent Pastore as Lenny Pescatore
- C.C.H. Pounder as Helene Washington
- Kim Raver as Victoria Keenan
- Ernie Sabella as Harland Bassett
- Christopher Shyer as Lawrence O'Malley
- Sharon Stone as Sheila Carlisle
- Betty White as Catherine Piper
- James Whitmore as Raymond Oz
- D.B. Woodside as Aaron Wilton
- Aunjanue Ellis as Sharon Young
- Michael Emerson as William Hinks
- Gina Gershon as Glenn Hall
- Christopher Reeve as Kevin Bealy
- Jon Cryer as Terry Pender
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