Production
"The Man with Two Brians" was written by John Viener and directed by Dominic Bianchi. In the storyboard animatic scene of Brian's rescue of a drowning Peter, music from Rambo: First Blood Part II was used. The scene in which Peter broke his neck and the design of New Brian were both based on drawings by creator Seth MacFarlane. New Brian was supposed to be a Golden Retriever, but his color was changed so that he would stand out from the yellow kitchen. In the scene when Peter wears the costume from The Greatest American Hero, the theme from E.T. was originally used. Several scenes were cut when the episode aired on television, mostly due to lack of time. The song New Brian sang to Peter was written by series writer Alec Sulkin. The original ending for the episode was a Beverly Hills, 90210 basketball joke, but it was cut.
"The Man with Two Brians", along with the first eight episodes of the seventh season were released on DVD by 20th Century Fox in the United States and Canada on June 16, 2009. The "Volume 7" DVD release features bonus material including deleted scenes, animatics, and commentaries for every episode.
Johnny Knoxville, star of Jackass, provided his own voice in this episode, and Will Sasso and Camille Guaty guest starred as various characters. The episode's writer, John Viener, provided the voice of New Brian. Recurring voice actors and writers Kirker Butler, Mark Hentemann, Danny Smith and Alec Sulkin made minor appearances in the episode.
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“Every production of an artist should be the expression of an adventure of his soul.”
—W. Somerset Maugham (1874–1965)