History of Testicular Immunology
- 460-377 BC Hippocrates described testicular inflammation associated with mumps
- 1785 Hunter and Michaelis performed transplant experiments in domestic chickens
- 1849 Berthold transplanted testes between roosters and showed maintenance of male sex characteristics only in birds with successfully grafted testes
- 1899-1900 Sperm recognized as immunogenic (will cause an autoimmune reaction if transplanted from the testis into a different area of the body) by Lansteiner (1899) and Metchinikoff, (1900)
- 1913-1914 Human testis transplants performed by Lespinasse (1913), and Lydson (1914) who performed a graft on himself!
- 1954 Discovery that sperm autoantibodies contribute to infertility,
- 1977 Billingham recognized that the testis is site of immune privilege
Read more about this topic: Testicular Immunology
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