TERF2

TERF2

Identifiers Symbols TERF2; TRBF2; TRF2 External IDs OMIM: 602027 MGI: 1195972 HomoloGene: 4133 GeneCards: TERF2 Gene

Gene Ontology
Molecular function	• chromatin binding • double-stranded telomeric DNA binding • protein binding • protein C-terminus binding • telomeric DNA binding • protein homodimerization activity
Cellular component	• chromosome, telomeric region • nuclear telomere cap complex • male germ cell nucleus • nucleus • nucleoplasm • nucleolus • cytoplasm • Golgi apparatus • Mre11 complex
Biological process	• telomere maintenance • age-dependent telomere shortening • in utero embryonic development • telomere maintenance via telomerase • cell cycle • telomere maintenance via telomere shortening • telomere capping • telomeric loop formation • protection from non-homologous end joining at telomere • negative regulation of telomere maintenance • positive regulation of telomere maintenance • negative regulation of telomere maintenance via semi-conservative replication • protein localization to chromosome, telomeric region • cellular senescence
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7014 21750 Ensembl ENSG00000132604 ENSMUSG00000031921 UniProt Q15554 O35144 RefSeq (mRNA) NM_005652 NM_001083118 RefSeq (protein) NP_005643 NP_001076587 Location (UCSC) Chr 16:
69.39 – 69.44 Mb Chr 8:
107.07 – 107.1 Mb PubMed search

Telomeric repeat-binding factor 2 is a protein that is also known as TRF2 and TRBF2. It is in humans encoded by the TERF2 gene.

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.