TBE can refer to:
- Tick-borne encephalitis
- TBE buffer, a buffer solution that consists of a mixture of tris base, boric acid, EDTA, and water
- Teledyne Brown Engineering
- Tetrabromoethane, a dense liquid used for mineral separation
- Tribromoethanol, an anesthetic agent with dangerous side effects
- To be elected, acronym
- The Black Eyed Peas, an American hip-hop group