Protein Transduction Domain
Tat contains a protein transduction domain, and is therefore known as a cell penetrating peptide. Originally characterised by Frankel and Pabo (1988) and Green and Loewenstein (1988), this domain allows Tat to enter cells by crossing the cell membrane. The amino acid sequence of the protein transduction domain is YGRKKRRQRRR. The nuclear localisation signal found within the domain, GRKKR, mediates further translocation of Tat into the cell nucleus. As of 2000 The biological role of this domain and exact mechanism of transfer is unknown.
Read more about this topic: Tat (HIV)
Famous quotes containing the words protein and/or domain:
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)
“You are the harvest and not the reaper
And of your domain another is the keeper.”
—John Ashbery (b. 1927)